Pleyotropiya (Yun. pleon – ancha ko’p sonli va tropos \u2014 burilish, yo’nalish) \u2014 genning ko’p tomonlama, ya’ni bir nechta belgilarning rivojla- nishiga ta’sir ko’rsata olish xususiyati. P. hodisasi genotip nazorat qilib tu- radigan reaktsiyalar mahsuloti daraja- sida o’zaro ta’sir ko’rsatadigan genlar sistemasi b-n bog’liq. Amalda har bir gen metabolizm jarayonining ma’lum bir bosqichini nazorat qiladi; hujay- Rada metabolitik jarayonlarning ko’p bosqichligi va xilma-xilligi tufayli biron bosqichda metabolizmning izdan chiqishi (bir gendagi mutasiya) keyingi bosqichlarning borishiga, binobarin, bir nechta belgilarga ta’sir ko’rsatadi. Bir gen mahsuloti (mas, ferment)ning bir nechta biokimyoviy reaktsiyalarda ish- tirok etishi,gemoglobin molekulasida polipeptid zanjirning sintezini na- zorat etuvchi gendagi resessiv mutasiya genning pleyotrop ta’siriga misol bo’la oladi. Bunday mutasiya gemoglobin molekulasining r – zan-jirida bitta aminokislota qoldig’ining (glutamin kislotaning valin b-n) almashinishini ta’minlaydi. Natijada eritrositlar- ning shakli o’zgarib, o’roqsimon (yarim oysimon) shaklga kiradi. Bu esa, o’z na- vbatida, yurak, kon aylanish, nerv, ovqat hazm qilish va ayirish sistemalari FA- oliyatining buzilishiga olib keladi. Bunday mutasiyaga nisbatan gomozigot (resessiv gomozi-gotali) bo’lgan odam bolalik davridayoq nobud bo’ladi.<\/p>\n","protected":false},"excerpt":{"rendered":"
Pleyotropiya (Yun. pleon – ancha ko’p sonli va tropos \u2014 burilish, yo’nalish) \u2014 genning ko’p tomonlama, ya’ni bir nechta belgilarning rivojla- nishiga ta’sir ko’rsata olish xususiyati. P. hodisasi genotip nazorat … Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":99837,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[226],"tags":[],"class_list":["post-119065","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-p-harfi","entry"],"translation":{"provider":"WPGlobus","version":"3.0.2","language":"kr","enabled_languages":["uz","kr","ru"],"languages":{"uz":{"title":true,"content":true,"excerpt":false},"kr":{"title":false,"content":false,"excerpt":false},"ru":{"title":false,"content":false,"excerpt":false}}},"_links":{"self":[{"href":"https:\/\/milliycha.uz\/kr\/wp-json\/wp\/v2\/posts\/119065","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/milliycha.uz\/kr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/milliycha.uz\/kr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/milliycha.uz\/kr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/milliycha.uz\/kr\/wp-json\/wp\/v2\/comments?post=119065"}],"version-history":[{"count":1,"href":"https:\/\/milliycha.uz\/kr\/wp-json\/wp\/v2\/posts\/119065\/revisions"}],"predecessor-version":[{"id":119090,"href":"https:\/\/milliycha.uz\/kr\/wp-json\/wp\/v2\/posts\/119065\/revisions\/119090"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/milliycha.uz\/kr\/wp-json\/wp\/v2\/media\/99837"}],"wp:attachment":[{"href":"https:\/\/milliycha.uz\/kr\/wp-json\/wp\/v2\/media?parent=119065"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/milliycha.uz\/kr\/wp-json\/wp\/v2\/categories?post=119065"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/milliycha.uz\/kr\/wp-json\/wp\/v2\/tags?post=119065"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}