GOFFMAN REAKTSIYALARI – alifatik aminlar olish uchun A. V. Goffman taklif etgan reaktsiyalar. Uch turi bor. 1) karbon kislotalar amidla- rining ishkrriy metallar gipogaloge- nidlari ta’sirida birlamchi aminlarga aylanishi (Goffman qayta guruxlani- shi): R+NaBrO -> RNH2+CO2+NaBr Reaktsiya natijasida Amidning kar- bonil guruhi SO2 holida ajralib chiqib, boshlang’ich amidlarga nisbatan bir uglerod atomi kam bo’lgan amin- lar hosil bo’ladi. G.r. spirtli muhitda o’tkazilganda reaktsiya mahsuloti sifati- da uretanlar (RNHOCOR) vujudga kela- Di. G.r. yordamida alifatik, yog’-aromatik, aromatik va geterosiklik aminlar, diaminlar va aminokislotalar olish mumkin. Sanoatda G.r. antroanil kis- lota sintez qilish uchun qo’llaniladi. Reaktsiya 1881 y.da kashf etilgan. 2) ammiakka alkillovchi reagentlar (galogenalkillar, dialkilsulfatlar va b.) ta’sir ettirib alifatik amin- lar olish. Reaktsiya mahsuloti sifatida birlamchi, ikkilamchi va uchlamchi amin- lar hamda to’rtlamchi ammoniy asosi aralashmasi hosil bo’ladi; mas, CH3J ishlatilganda [CH3NH3]J; [(CH3)2NH,] J; [(CH3)3NH]J va [(CH3)4N]J hosil bo’ladi. Reaktsiya 1850 y.da kashf etilgan. 3) to’rtlamchi ammoniy asosli gidroksid- larning termik parchalanishi natijasi- da o’lchamli aminlar va olefinlar hosil bo’lishi [RCH2CH2 N R’R”R”]OH—– ————>RCH=CH2+R’R’R*>I+H2O . Agar to’rtlamchi azot atomi turli o’rinbosarlar b-n bog’langan bo’lsa, qo’sh bog’li, tarkibida eng kam sonli alkil o’rinbosarlari bo’lgan olefin hosil bo’ladi (Goffman qoidasi). G.r. qo’llanishining muhim yo’nalishi Alka- loidlarning tuzilishini tekshirishdir. Reaktsiya 1851 y.da kashf etilgan.<\/p>\n","protected":false},"excerpt":{"rendered":"
GOFFMAN REAKTSIYALARI – alifatik aminlar olish uchun A. V. Goffman taklif etgan reaktsiyalar. Uch turi bor. 1) karbon kislotalar amidla- rining ishkrriy metallar gipogaloge- nidlari ta’sirida birlamchi aminlarga aylanishi (Goffman … Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":99837,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[210],"tags":[],"class_list":["post-131088","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-g-harfi-2","entry"],"translation":{"provider":"WPGlobus","version":"3.0.2","language":"kr","enabled_languages":["uz","kr","ru"],"languages":{"uz":{"title":true,"content":true,"excerpt":false},"kr":{"title":false,"content":false,"excerpt":false},"ru":{"title":false,"content":false,"excerpt":false}}},"_links":{"self":[{"href":"https:\/\/milliycha.uz\/kr\/wp-json\/wp\/v2\/posts\/131088","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/milliycha.uz\/kr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/milliycha.uz\/kr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/milliycha.uz\/kr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/milliycha.uz\/kr\/wp-json\/wp\/v2\/comments?post=131088"}],"version-history":[{"count":1,"href":"https:\/\/milliycha.uz\/kr\/wp-json\/wp\/v2\/posts\/131088\/revisions"}],"predecessor-version":[{"id":131096,"href":"https:\/\/milliycha.uz\/kr\/wp-json\/wp\/v2\/posts\/131088\/revisions\/131096"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/milliycha.uz\/kr\/wp-json\/wp\/v2\/media\/99837"}],"wp:attachment":[{"href":"https:\/\/milliycha.uz\/kr\/wp-json\/wp\/v2\/media?parent=131088"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/milliycha.uz\/kr\/wp-json\/wp\/v2\/categories?post=131088"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/milliycha.uz\/kr\/wp-json\/wp\/v2\/tags?post=131088"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}